Heart Disease Self-Scheduler

Basic Criteria: 

• Be 18+ with at least one of the following. 

• • Coronary artery disease (CAD) 

• • Heart attack 

• • Coronary artery score (CAC) >400 

• • History of surgical or percutaneous coronary revascularization procedure. Examples: Coronary Artery Bypass grafting, Percutaneous Coronary Interventintion, Endarterectomy, Transmyocardial laser Revascularization  

• • Stroke (ischemic, hemorrhagic or unknow type) 

• • Peripheral arterial disease (PAD) defined as either intermittent claudication within the last 12months OR prior nontraumatic amputation or peripheral procedure (stenting or surgical revascularization)  

OR 

• Be 55+ with high risk for CVD with at least 2 of the following  

• • Age ≥ 70 years  

• • Chronic kidney Disease  eGFR <60 

• • Current smoker-clarify 

• • AFIB and on medical therapy (anticoagulation or rate control) 

• • Most recent CAC score >100 

• • Type 1 or 2 diabetes, BMI≥ 30 or BMI ≥ 27 if East Asian, South East Asian or South Asian decent 

• • Treated high blood pressure, on a stable dose for 30days with a thiazide, thiazide-like or loop diuretic AND at least one other standard care of Blood pressure meds for any of these drug classes: ACE inhibitor or ARB, Calcium channel blocker, Beta blocker, MRA, Vasodilator (hydralazine, minoxidil, alpha blocker) or centrally acting antihypertensive medication (e.g. clonidine)  

• • Blood pressure range ≥ 145mmHg and <180mmHg Systolic

Answers Must Be No: 

• If female of childbearing potential, are you currently pregnant, breastfeeding, or planning to become pregnant?   

• In the past 12months have you had any alcohol or substance use disorder? 

• Are you currently taking both an ARB and an ACE inhibitor (either as a single medication or part of combination medications? 

• Is your high blood pressure because of other conditions including but not limited to history of renovascular hypertension, primary aldosteronism, pheochromocytoma, Cushing syndrome, or aortic coarctation? 

• • Exception: high blood pressure due to CKD. 

• Do you have a condition where blood pressure drops significantly when a person stands up from a sitting or lying position? 

• If diabetic, have you had an A1C >10 % in the past 2 months? 

• Have you lost >10% of weight in the past 3months? Patients on drugs that cause significant weight loss like GLP-1 must be on stable dose for at least 3months. 

• Do you have any history of or current liver cirrhosis? 

• Do you have any active HIV infection? Exception: Patients on antiretroviral clinical stable and compliant with treatment for at least 6months 

• Have you received any investigation product in the past 30days? 

• In the past 3 months, have you used a potassium binder for the treatment of hyperkalemia? 

• Do you have any sever respiratory disease, NYHA class IV heart failure, cancer in the past 5 years or any other condition that could limit participation for the duration of the study? Exception: non-melanoma skin cancer 

• Have you undergone major organ transplant or anticipate doing so during the study? 

• In the past 6 months, have you been treated or anticipate being treated with any therapeutic agent that targets AGT? Examples:  Cozaar, Benicar, Atacand, Diovan, Avapro, Micardis ,Edarbi 

• Do you have any current or history of severe intolerance (e.g. angioedema, recurrent hyperkalemia, recurrent acute kidney injury) to an ARB or ACE inhibitor other than cough?  

• Have you had any significant CV events like heart attack, stroke, revascularization procedure or been hospitalized for heart failure in the past 60 days? 

• Do you have severe aortic stenosis, a condition where the aortic valve controlling blood from the heart to the body becomes narrowed and does not open properly? 

• Are you currently placed in an institution based on an official or court order? 

Answers Must be YES 

• Are you able to sign consent and comply with all study requirements? 

• If female of childbearing potential, do you agree to use a highly effective method of contraception as listed below from at least 1 prior completed menstrual cycle through 12months after last dose administration?  

• • Oral, Implantable, transdermal, injectable methods associated with inhibition of ovulation 

• • Intrauterine device (IUD)  

• • Intrauterine hormone-releasing system (IUS)  

• • Bilateral tubal occlusion 

• • Have a partner who is vasectomized or sterile due to medical cause. Must bring documentation. 

• • Sexual abstinence if preferred and usual lifestyle 

• If female of non-childbearing potential, do you meet one of the following requirements? 

• • Postmenopausal defined as no cycle for 12 months without an alternative medical cause.  

• • Documented: hysterectomy, bilateral salpingectomy, bilateral oophorectomy 

  Additional criteria will apply 

Compensation up to $1,150 may be available for time and travel

Insurance is not required 

PLEASE NOTE: If you do not see an available appointment, please call 210-714-0067 for availability