Major Depressive Disorder Self-Scheduler

Basic Criteria: 

• 18-85 years old 

• Diagnosed with Major Depressive Disorder (MDD) 

• Taking a stable dose of antidepressant medication for at least one month 

• BMI less than or equal to 40 

Additional criteria will apply 

Answers Must Be No: 

• If female of childbearing potential, are you pregnant, breastfeeding, or planning on becoming pregnant?  

• Do you have a current or previous diagnosis of ADHD, Schizophrenia or other severe psychotic disorders (such as bipolar disorder, schizoaffective disorder, brief psychotic disorder, or borderline personality disorder)? 

• Do you have any first-degree relatives with a history of schizophrenia, schizoaffective disorder, or bipolar disorder type 1? 

• Have you had electroconvulsive treatment, transcranial magnetic stimulation, deep brain stimulation, or vagal nerve stimulation for any episode of MDD in the last 6 months? 

• Are you currently receiving treatment or been treated in the past 14 days with a monoamine oxidase inhibitor, tricyclic antidepressant, mirtazapine, trazodone, moclobemide, buspirone, an antipsychotic, Mood stabilizers or St John’s Wart? 

• Are you currently using or been treated in the past 14 days with any other prescription or over-the-counter drugs besides antidepressants and high blood pressure medications? 

• Do you have uncontrolled high blood pressure, hypothyroidism or hyperthyroidism that is not managed by stable medication for 3+ months? 

• Have you used psilocin or any other psychedelics more than 4 times over your lifetime or used any psychedelics in the past 12 months? 

• Have you used ketamine in the past 12 months? 

• Do you currently or have you previously had a brain disorder (e.g. epilepsy, seizures, intracranial hypertension, intracranial bleed, aneurysmal disease, or another medical condition associated with seizures or convulsions)? 

• Have you ever had Serotonin Syndrome?  

• Do you have a history of substance use disorder in the past year?  

• Have you donated blood or plasma in the past 1 month? 

• Do you have any other significant medical or surgical history that would make you unfit for study participation? 

Answers Must Be Yes: 

• Have you been diagnosed with Major Depressive Disorder (MDD)? Can you provide documented evidence of diagnosis from a registered health care provider?  

• Are you able to pass an alcohol or drug test at screening? 

• If you’ve only had a single episode of MDD, did it last from 1 to 6 months? 

• If you are 60 years or older, did your first MDD episode occur prior to turning 60? 

• Have you been taking a stable dose of antidepressant medication for at least 1 month?  

• Are you willing to consent to video and audio recordings of psychological support and dosing sessions for the duration of the study? 

• If female of childbearing potential and sexually active, are you willing to use at least one highly effective method of contraception in addition to use of condoms? 

• If male and sexually active with a female of childbearing potential, are you willing to use a highly effective method of contraception? 

Additional criteria will apply 

Compensation may be available for time and travel

Insurance is not required 

PLEASE NOTE: If you do not see an available appointment, please call 210-714-0067 for availability