High Cholesterol Self-Scheduler

Basic Criteria 

Age Requirements: 

• Must be between 18 and 64 years old 
• Must have a Primary Care Physician to process medical record requests

Current Conditions: 

• Must have cholesterol levels of 100 mg/dL or higher on fasting blood test 

• Must either be new to cholesterol medications OR have been off specific cholesterol treatments for required time periods 

• Cannot be planning to start any cholesterol medications during screening 

Answers Must Be NO 

1. Are you currently pregnant, trying to get pregnant, or breastfeeding? 
2. Do you routinely drink more than 2 alcoholic drinks per day? 
3. Have you had problems with drug abuse in the past year or are you currently using illegal drugs? 
4. Do you have uncontrolled high blood pressure with readings consistently above 160/100 mmHg despite medication? 
5. If diabetic, is your A1C ≥9.0%? 
6. Are you currently taking any of these medications: cyclosporine, certain antiviral medications, gemfibrozil, regorafenib, darolutamide, enasidenib, teriflunomide, capmatinib, fostamatinib, febuxostat, tafamadis, cholestyramine, colchicine, ticagrelor, warfarin, or high-dose niacin (1 gram or more daily)? 
7. Are you currently in another research study or have you been in one within the past 3 months? 
8. Are you unwilling to take statin medications, or have you had serious side effects or allergic reactions to statin medications in the past? 
9. Have you had a heart attack, stroke, coronary procedures, or other major cardiovascular events in the past 3 months? 
10. Are you currently receiving chemotherapy for cancer or have you had any cancer (except skin cancer) in the past 3 years? 
11. Do you have active liver disease or have recent blood tests shown liver problems? 
12. Have you ever had myopathy, myositis, rhabdomyolysis (serious muscle breakdown), or unexplained muscle pain and weakness from medications? 
13. Do you have advanced heart failure that severely limits your daily activities or have you been hospitalized for heart failure in the past 3 months? 
14. Do you have severe kidney disease requiring dialysis or have you been told your kidney function is severely reduced (eGFR less than 30, typically stage 4 &5 )? 
15. Have you had LDL apheresis treatments (a procedure to remove cholesterol from blood) in the past 3 months or are you planning to start these treatments? 
16. Have you been told you have high triglycerides (above 400 mg/dL if known)? 
17. Are you currently engaged in vigorous exercise training such as marathon training or bodybuilding or plan to do so? 
18. In the past 3 months, have you experienced any recurrent vomiting, inflammatory bowel disease with ongoing symptoms, chronic intestinal disease accompanied by a disturbance in digestion absorption, or have a history of extensive resection of the upper GI tract? 
19. Have you had elevated creatine kinase levels (a muscle enzyme) above 3 times the normal limit, or a history of unexplained muscle enzyme elevations? 
20. Have you had an organ transplant or do you have major heart, lung, or abdominal surgery planned in the next 5 months? 
21. Do you have HIV infection or AIDS? 
22. Have you ever been diagnosed with nephrotic syndrome (a serious kidney condition causing protein loss)? 
23. Do you identify as being of Asian descent or heritage? 
24. Do you have a personal or family history of hereditary muscular disorders or genetic muscle diseases? 
25. Have you been diagnosed with homozygous familial hypercholesterolemia (a severe genetic form of high cholesterol) or other rare inherited cholesterol disorders? 

Answers Must Be YES 

1. Do you have a primary care physician?
2. Are you willing and able to follow fasting instructions (no food or drink except water for 8+ hours before dosing and clinic visits)? 
3. If you are a woman who could become pregnant, are you using highly effective birth control (birth control pills, IUD, implant, sexual abstinence, or other highly effective method) and willing to continue for 8 weeks after the study medication? 
4. If male, are you willing to use condoms during the study and continue for 8 weeks after study medication? 
5. Are you willing to commit to taking daily study medication and attending all required visits over approximately 6 months? 

Compensation may be available for time and travel

Insurance is not required 

PLEASE NOTE: If you do not see an available appointment, please call 210-714-0067 for availability