Overweight & Obesity Research Self-Scheduler

Basic Criteria 

• Are you between 18 and 80 years old? 

• Do you have a BMI of 30 or higher, OR a BMI of 27-29 with at least one of the following: 

• • High blood pressure (on medication or blood pressure 130-159 systolic or 80-99 diastolic) 

• • High cholesterol or triglycerides (on medication or elevated lab values) 

• • History of heart disease (like heart attack or stroke) 

• • Sleep apnea 

• Must be on a stable weight for the last 3 months (no more than 5% change) 

Answers Must be NO 

• Have you ever been diagnosed with type 1 or type 2 diabetes? (Note: Gestational diabetes history is okay if current labs are normal) 

• Have you used any of the following weight loss medications in the past 6 months: 

• • Wegovy, Ozempic, Rybelsus (semaglutide), Saxenda (liraglutide) 

• • Zepbound, Mounjaro (tirzepatide), or Any other GLP-1 medication 

• Are you allergic or have you had bad reactions to any GLP-1 medications (medications like Ozempic, Wegovy, Saxenda, Mounjaro, or Zepbound)? 

• Do you or anyone in your immediate family (parents, siblings, children) have a history of thyroid cancer or multiple endocrine neoplasia? 

• Are you currently pregnant or breastfeeding or planning to become pregnant during the study or for 60 days after? 

• Have you had weight loss surgery like gastric bypass, sleeve gastrectomy, or Lap-Band? 

• Have you had procedures for weight loss like gastric balloon or ablation in the past 6 months? 

• Do you plan to have any weight loss surgery or procedures during the study? 

• Have you had an organ transplant (other than cornea)? 

• Do you have uncontrolled thyroid problems? 

• Do you have uncontrolled high blood pressure (over 160/100)? 

• Do you have a history of frequent or severe low blood sugar episodes? 

• Do you drink more than 21 alcoholic drinks per week (for men) or 14 drinks per week (for women)? 

• Do you use recreational drugs? 

• Are you currently taking or have you taken in the past 3 months: 

• • Metformin (diabetes medication) 

• • Weight loss medications like Contrave, Qsymia, Xenical, Alli, or phentermine 

• • Medications that cause significant weight gain like certain antidepressants (tricyclics like amitriptyline, paroxetine) or antipsychotics (like olanzapine, clozapine) 

• • Central nervous system stimulants like Adderall, Ritalin, or Vyvanse (caffeine is okay) 

• • Systemic steroids for more than 2 weeks (inhalers, nasal sprays, and joint injections are okay) 

• Have you been diagnosed with obesity caused by a hormone disorder like Cushing’s syndrome? 

• Have you been diagnosed with genetic obesity conditions like Prader-Willi syndrome? 

• Have you been diagnosed with severe gastroparesis (severe delayed stomach emptying) or gastric outlet obstruction? 

• Have you ever had pancreatitis (inflammation of the pancreas)? (Note: History of pancreatitis from gallstones is okay if gallbladder has been removed) 

• Do you have inflammatory bowel disease like Crohn’s disease or ulcerative colitis? 

• In the past year, have you had any of the following: Heart attack, Stroke, Unstable angina (severe chest pain), Hospitalization for congestive heart failure 

• Do you have ongoing or frequent heart rhythm problems like atrial fibrillation or other tachycardia conditions? 

• Have you been diagnosed with severe heart failure (New York Heart Association Class III or IV)? 

• Do you or anyone in your immediate family have long QT syndrome? 

• Have you had unexplained fainting episodes in the past year? 

• Do you have any active liver disease other than fatty liver disease? 

• Do you have severe kidney disease or kidney failure (stage 4 or 5)? (eGFR must be ≥30) 

• Do you have active gallbladder disease? (Note: History is okay if gallbladder has been removed) 

• Have you had cancer (other than skin cancer or certain early-stage cancers) diagnosed or treated within the past 5 years? 

• Do you have HIV, hepatitis B, or hepatitis C? 

• Have you had any autoimmune condition requiring treatment with steroids in the past 6 months? 

• Have you had major depression or other serious psychiatric disorder (like schizophrenia or bipolar disorder) that was not stable in the past 2 years? 

• Have you ever had a suicide attempt or suicidal thoughts? 

• Do you have a history of eating disorders like anorexia or bulimia? 

• Are you currently taking medications that significantly prolong the QT interval on heart tracings? (like certain heart rhythm medications or some antibiotics) 

• Do you chronically take medications that directly affect how fast your stomach empties? 

• Have you donated a pint of blood in the past 8 weeks? 

• Have you had a blood transfusion or severe blood loss in the past 3 months? 

• Are you currently enrolled in another research study, or have you been in one in the past 90 days? 

Answers Must be YES 

• Are you willing to use effective birth control during the study and for 60 days after? 

• Are you able to swallow tablets? 

• Are you willing and able to attend all study visits over approximately 6 months?